改性果胶成分的生物学活性

 《活性糖类与膳食纤维》 2013，（1） 21－37

摘要

本文讨论了果胶的结构，改性工艺对于制备改性果胶的影响以及改性果胶的生物学活性。研究表明，果胶片段选择性结合促转移调节蛋白半乳糖凝结素-3（GAL-3），这种结合能显著预防和降低癌症发生。文章对于口服果胶在机体内可能的吸收和运输模式进行了思考，讨论了与果胶活性类似的膳食性碳水化合物如β-葡聚糖在体内的吸收机理，这些物质通常具有免疫调节和抗癌活性。文中最后讨论了其他膳食性碳水化合物作为GAL-3抑制剂， GAL-3和其他半乳糖凝集素在细胞和组织稳定中的起到的作用。这些结果表明，果胶产品能有效抑制各类慢性疾病。

The bioactivity of modified pectin fragments 

Victor J. Morrisn, Nigel J. Belshaw, Keith W. Waldron, Ellen G. Maxwell.

Bioactive Carbohydrates and Dietary Fibre, 2013, (1) 21–37  

Abstract

This review discusses the structure of pectin, the effects of modification procedures used to prepare modified pectins, and the evidence for the bioactivity of these modified materials. It will consider the evidence for the selective binding of pectin fragments to the pro-metastatic regulatory protein galectin-3 (Gal3) and the potential effects of such binding on reducing the risks of the onset and prevention of cancer. The possible modes of uptake and transport by the body of orally consumed pectin will also be considered. In this context the uptake mechanisms for other dietary carbohydrates that show immunomodulating and anti-cancer properties, such as theb-glucans, will be discussed in terms of possible analogous behaviour for pectin. Finally the article will also consider other dietary carbohydrates that might provide a source of inhibitors for Gal3 and the possible roles of Gal3 and other members of the galectin family in cellular and tissue homeostasis that suggest potential roles for pectin-derived components in combating a range of chronic diseases.