欢迎访问浙江果源康品生物科技有限公司官方网站!

文献资料

联系我们

浙江果源康品生物科技有限公司

电话:0570-8788056

传真:0570-8788381

邮箱:zjgykp@163.com

地址:浙江省衢州市东港经济开发区

东港4路2号

您所在的当前位置:首页 > 文献资料 > 肿瘤类文献
  • 果胶与癌症治疗综述
  • 发布时间: 2019/4/17 点击次数:1816 
  •  

    果胶与癌症治疗综述

    作者:张文博,Ping Xub,Han Zhanga

      a.新乡医科大学生命科学与技术学院,河南新乡453003

    (电话:D86 373 3831928;传真:D86 373 3029887;

    电子邮件:zhangwenbo@xxmu.edu.cn)(电子邮件:zhanghan317@163.com)

    b新乡医科大学药学院

    河南新乡45300(电子邮件:13273730271@163.com)

     

    果胶是一类复杂的植物多糖,由半乳糖醛酸和中性糖侧链组成。据报道,天然果胶可作为膳食纤维(DF)预防结肠癌。为了提高其生物利用度和生物活性,果胶被改造成生物可利用的具有低分子量的改性果胶(MPs)。此外,MPs具有低酯化度(DE),据报道它有抑制肿瘤生长,诱导细胞凋亡,抑制转移和调节免疫的作用。 MPs的抗肿瘤活性源于半乳糖凝集素-3(Gal-3)对配体识别的干预。此外,由于其丰富的改性功能团和特殊的物理化学性质,果胶是抗癌药物递送系统的合适载体。在这里,我们总结了结构特征,生物吸收和抗肿瘤机制以及MPs的结构 - 活性关系。我们还为将果胶开发成保健品或药物提供了前景和挑战。

    Pectin in cancer therapy: A review
    Wenbo Zhanga,*, Ping Xub and Han Zhanga
      aSchool of Life Sciences and Technology, Xinxiang Medical University, Xinxiang 453003, Henan, China
    (Tel.: D86 373 3831928; fax: D86 373 3029887;
    e-mail:
    zhangwenbo@xxmu.edu.cn)
    (e-mail:
    zhanghan317@163.com)
    School of Pharmacy, Xinxiang Medical University,
    Xinxiang 453003, Henan, China
    (e-mail:
    13273730271@163.com)

     


    Pectin, a complex class of plant polysaccharides, is composed of a galacturonan backbone and neutral sugar side chains. Natural pectin is reported to prevent colon cancer as a dietary fiber (DF). To enhance its bioavailability and bioactivity, pectin was modified into bioavailable modified pectin fragments(MPs) with low molecular mass. Also, MPs had low degrees of esterification (DE) which is reported to inhibit tumor growth, induce apoptosis, suppress metastasis, and modulate immuno- logical responses. Antitumor activity of MPs chiefly arises from intervention in ligand recognition by galectin-3 (Gal-3). In addition, pectin is a suitable vehicle for anti-cancer drug deliv- ery systems, due to its abundant modifiable functional groups and special physicochemical properties. Here, we summarize the structural features, bio-absorption and antitumor mecha- nisms and the structure-activity relationship of MPs. We also offer prospects and challenges for developing pectin into nu- traceuticals or drugs.

     

  • 上一篇:低分子柑橘果胶联和临床常用化疗药用于控制癌症和癌症转移扩散
    下一篇:Galectin-3抑制神经性疼痛周围神经损伤后衰减
  • 返回新闻列表